Biography:

Li Niu has completed his PhD at the age of 30 years from Changchun Institute of Applied Chemistry and postdoctoral studies from Åbo Akademi Unversity, Finland. Now, he is the director of Engineering Laboratory for Modern Analytical Techniques, CIAC, CAS, and also is RSC fellow. He has published more than 200 papers (H-index 41) in reputed journals and has been serving as editorial board members in several journals.

Abstract:

Engineering Laboratory for Modern Analytical Techniques, c/o State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Email: lniu@ciac.ac.cn, Webpage: http://lniu.ciac.jl.cn Electrochemistry technique is an important member in the whole family of the instrumental analysis. Especially, in coupling with other techniques, we can know much information about the interfacial interaction, structural features, reaction process, mass transfer, etc. during electrochemical running. Unfortunately, imported instruments & equipment occupies the leading position in China within the past decades, electrochemistry system is also still the world of imported products in China, such as Princeton, CHI, BAS, Gamry, Biologic, etc. Besides those electrochemical instruments, some typical and daily-used electrochemical sensors, such as blood glucose analysis, industrial control gas sensors, heavy metal ion monitoring, blood gas analysis, met the same problem in China. With great increase of human industrial production, water quality analysis is becoming more and more necessary. A few typical electrochemical devices and methods for water monitoring, such as DO, COD, heavy metals, etc. have been developed successfully. In addition, various methods and sensors for bioanalysis & food analysis have been explored too. Furthermore, series of electrochemical instruments have been completed, which ranged from basic model to advanced, from potentiostat to bipotentiostat, even to multichannel, from integrated spectrometers to electrochemical imaging & etching components, etc. Those developed instruments have been widely used in many institutes & universities in China. Finally, the authors gratefully acknowledge the support of K. C. Wong Education Foundation, Hong Kong.

Biography:

Kent Peterson serves as President and CEO of Fluid Imaging Technologies, Inc, a Scarborough-based emerging growth technology firm providing image-based analysis of cells and particles in a fluid medium for numerous applications. Fluid Imaging has sold instruments into over 40 countries around the world. Mr. Peterson has been named Mainebiz Leader of the Year in the small business category. Fluid Imaging won the U.S. S.B.A. New England Exporter of the year award, the Maine International Trade Center’s Exporter of the Year and the Portland Regional Chamber’s Robert R. Masterton Award.

Abstract:

Flow Imaging particle analysis has shown great promise for analysis of sub-visible particulates in parenterals, especially for protein aggregates. The ability to detect transparent particles, along with the ability to differentiate them based upon shape parameters, yields significantly more detailed and accurate information than can be acquired using common laser diffraction and light obscuration techniques. The addition of color information, along with sophisticated statistical pattern recognition algorithms, can also enable these systems to differentiate and quantify silicon oil droplets and air bubbles found in parenterals. This presentation will present the techniques used to accomplish this.

Biography:

Yu Bao, doctor, associate researcher in Engineering Laboratory for Modern Analytical Techniques, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

Abstract:

Smartphones for sensing: Simple, portable analytical devices are entering our daily lives for personal care, clinical analysis, allergen detection in food, and environmental monitoring. Smartphones, as the most popular state-of-art mobile device, have remarkable potential for sensing applications. A growing set of physical-co-chemical sensors have been embedded; these include accelerometer, microphone, camera, gyroscope, and GPS units to access and perform data analysis. In this review, we discuss recent work focusing on smartphone sensing including representative electromagnetic, audio frequency, optical, and electrochemical sensors. The development of these capabilities will lead to more compact, lightweight, cost-effective, flexible, and durable devices in terms of their performances.

Biography:

Dr. Zahir Akhunzada a PPD Consultant in the Analytical & Bioanalytical Development department at Bristol-Myers Squibb in New Brunswick, New Jersey where he is responsible for the analysis and characterization of proteins by MFI and related techniques. Before joining PPD, he worked for Schering-Plough/Merck. He was Assistant Prof. at King Saud University Riyadh Saudi Arabia and a Guest Investigator at the VA Hospital in Newark,

Abstract:

The presence of sub-visible particles (SVPs) is a major challenge in the development of therapeutic protein formulations. Distinction between proteinaceous and non-proteinaceous SVPs is vital in monitoring the formulation stability. The current compendial method based on light obscuration (LO) has limitations in analyzing translucent particles, requires large analysis volume and therefore demands urgent need for an unambiguous method to characterize SVPs. A number of attempts have been made to characterize SVPs, albeit with limited success. This presentation reveals a method that successfully characterizes and distinguishes, both potentially proteinaceous and non-proteinaceous SVPs in protein formulations by using Microflow Imaging (MFI) in conjunction with the MVAS (MFI View Analysis Suite) software

Biography:

Mr. Michiyuki has completed his Master’s degree at the age of 24 years from Kyushu University. He has worked as a researcher, focusing on the development of genetic clinical diagnosis in Eiken Chemical Co., LTD. since 2011.

Abstract:

Nucleic acid amplification tests (NAATs) have become common tools for detecting pathogens in clinical samples. Among NAATs, loop-mediated isothermal amplification (LAMP) assay, which enables DNA amplification and detection at constant temperture, has the advantages of reaction simplicity, amplification efficiency and also inexpensiveness compared to PCR-based technologies. Quantitative analysis in NAATs have been performed by kinetic analysis of amplification reactions as in so-called “real-time PCR method” and this aproach has found to be applicable to LAMP assay as well. However, these assay require sophisticated instruments and well-trained laboratory staffs to obtain accurate and reproducible results. This limitation has been a main obstacle to expand this type of quantitative LAMP assay to point of care tests in resorce limitting facilities. In this study, we developed simple and rapid semi-quantitative LAMP assay based on multi-well dispensing method (mult-well qLAMP). In the presentation, we will demonstrate that our novel technology is sufficient to distinguish some criterion of DNA levels with high reproducibility, and highly correlative to conventional quantitative LAMP assay. We expect that this technology can be applicable as point of care tests to help determination of treatment eligibility, especially in infectious deseases whose amont of pathogenic DNA is a crucial criteria of defining treatment strategy

Biography:

Yi has completed his PhD in chemistry from Division of Chemistry and Biological Chemistry, Nanyang Technological University Singapore in 2010. He is currently a senior analytical scientist of Abbott Nutrition Research and Development, Singapore.
 

Abstract:

The purpose of this research method is to determine sugar profile (mono- and disaccharides) of Abbott nutritional products in fulfillment of the “Sugar” label claim. In this method, the sugars (galactose, glucose, fructose, sucrose, lactose and maltose) were extracted from product primarily by dilution in water.  The sugars were analyzed via high performance anion exchange coupled with pulsed amperometric detection (HPAEC/PAD).  The HPAEC/PAD Dionex ICS5000 system was equipped with a triple pulsed electrochemical cell (ED) with a pH reference electrode (Ag/AgCl), a gold working electrode, and a borate trap in tandem with a PA1 analytical column. Quantitation was accomplished using a six level quadratic curve and peak area.

Sugars are analyzed by HPAEC/PAD via a new gradient elution program to ensure adequate resolution of the analytes of interest and known interferences from AN commodities. Method specificity was successfully evaluated by comparing the retention times of a sugar standard mix vs commonly used commodities and ingredients. Method accuracy and precision were evaluated by comparing results generated for AN research samples using this research method relative to third party laboratory results.

Biography:

Marc Rippen holds degrees in Analytical Chemistry, Microbiology, form FAU, A Master of Science in Aeronautics from Embry Riddle Aeronautical University, and is completeing his PhD in Engineering and Technology Management at NCU. He is the CEO of Alertgy, a company he founded to develop and commercialize a non intrusive blood sugar monoitor and alert system. He is the former Director of Engineering at SRI for their marine and space science division, holds numerous US and World-wide patents and has published more than a dozen papers in reputed journals. As an expert consultant he provides commercializationm assessments for SBIR and STTR research projects for government agencies such as NASA, DOD, DOE, NSF as well as for various university research institudes to determine the commercial viablity and best path to market for technolgies developed during research activities

Abstract:

Current glucose monitoring devices are based on devices originally created in the 1960’s. They have been made smaller are easier to use and can log data, their measurements basically are the same as the first laboratory sensors. The patent must prick their fingure so they can squeeze a droplet of blood on a strip coated with an enzyme (usually glucose oxidase) that reacts to form hydrogen peroxide from the available glucose and oxygen. The hydrogen peroxide generated is then measured amperometrically with an electrode. The cost, inconvienance and pain incurred in using these systems has lead to heavy research to develop non-invasive glucose monitoring techniques. The major current areas of research and the sensor technologies they use will be discussed. The techniques to be covered include interstitial fluid chemical analysis, breath chemical analysis, infrared spectroscopy, optical coherence tomography, temperaturemodulated localized reflectance, raman spectroscopy, polarity changes, ultrasound, fluorescence, thermal spectroscopy, ocular spectroscopy, and impedance spectroscopy.

Biography:

V. A.  Krylov, Doctor of Chemistry, Professor, Head of the Division of Analytical Chemistry of the Nizhny Novgorod State University. The main direction of scientific research of Professor Krylov is the development of the theory and applications of chromatography, chromatography–mass spectrometry for the analysis of high purity substances, including monoisotopic compounds, environmental objects and for the development of methods of the micropreconcentration of impurities. The attained detection limits for molecular impurities constituted 10^–6 to 10^–11 wt % and hit a record low. He is the author of more than 200 scientific papers, including reviews on the analytical chemistry of high purity volatile substances, the determination of organic substances in air, and liquid-liquid  microextraction preconcentration

Abstract:

Esters of phthalic acid are very dangerous for human health. Their penetration into the organism leads to the occurrence of cancer, disease of liver, kidney, reproductive organs. Phthalates are very widespread toxicants. Their occurrence in wines is connected with the inflow from the plasticized polymer seals, plastic piping, tanks and stoppers. In this study the  high sensitive gas chromatographic-mass spectrometric determination of phthalates in low alcoholic beverages (champagne, red and white wine) coupled ultrasound-assisted emulsification-microextraction was  developed. As extractants environmentally friendly hydrocarbons - octane and n-hexane are proposed. The sources of possible systematic errors were investigated:   leaking of o-phthalates from chromatographic septum; contamination of phthalate in solvents; influence of macro components of wines; the hydrolysis of o-phthalates and others. For the first time it is shown that the impact of these factors can lead to an overestimation or underestimation of the actual concentration of impurities by 1-2 orders of magnitude. The methods of accounting or elimination of systematic errors are proposed. Purification of solvents by Rayleigh distillation method allows to obtain samples with impurity content lower than (1-4)∙10-3 mgL^-1. It is shown that the duration of storage of wine samples prior to analysis should not exceed three days. Containers for sampling and storage of samples to be analyzed should be made of borosilicate glass or quartz. The content of phthalates in wines was 0.03 - 1 mgL^-1. The largest concentrations are characteristic for diethyl-, di-n-butyl-  and di(2-ethylhexyl) phthalates. The limits of detection of esters of о-phthalic acid in low alcohol beverages achieved are at the level of 10^-6–10^-5 mgL^-1 and are highly competitive with the best world results. The relative expanded uncertainty of the determination of toxicants of 13- 30%.

Biography:

Dr Martin Enemchukwu has completed his PhD in Chemistry from University of South Africa (Unisa). He is currently a lecturer and the Extended Science Pathway supervisor at Unisa. In his current position, he has helped Unisa kick start a foundation provision programme that supports students academically in the science degrees and diplomas. He has co-authored more than 5 papers in reputed journals. He is the founding member of the Ecotoxicology Research Niche Area (RNA) being hosted by the Chemistry department of the same university. His research area focuses on the effective fabrication and use of ion selective electrodes in the monitoring of harmful chemical pollutants in our environment.

Abstract:

In this study solid-state ion selective electrodes which are sensitive to inorganic phosphate ions have been prepared. The solid salts used in the electrodes membranes composition were aluminium powder (Al), Aluminium phosphate (AlPO₄) and powdered copper (Cu). The principal component of the electrodes was Aluminium phosphate (AlPO₄). Studies on phosphate detection in solution were conducted by varying the quantities of the principal component and the other membrane components in a particular membrane under the same conditions. In some cases, a membrane component is entirely omitted and effects on phosphate detection observed. The mechanism for the selectivity of phosphates by the electrodes includes adsorption, absorption and ion-exchange processes. An understanding of these processes reveals that the composition of the membrane material and its molecular structural framework are all important. The ternary membrane electrodes exhibited linear potential response in the concentration range of 1.0 × 10⁻¹M to 1.0 × 10⁻⁶M. The electrodes have a long lifetime and can be stored in air while not in use.